Pttg1 and p53

Author: yzhw

August undefined, 2024

WebOct 6, 2015 · In our hands, p53 transcriptionally activated the expression of these miRNAs in pituitary tumor cells. Finally, we found that PTTG1 could inhibit p53 transcriptional activity to the four miRNAs. These data indicate the existence of a feedback loop between PTTG1 targeting miRNAs, PTTG1 and p53 that promotes pituitary tumorigenesis. WebNov 18, 2014 · A well-described example is the human securin pituitary tumor-transforming gene 1 (PTTG1) which is a marker for invasive colorectal carcinoma 14 and was identified as a key signature gene associated with tumor metastasis 15. The functional interaction between PTTG1 and p53 has been demonstrated in transformed cells 16, 17.

Human securin interacts with p53 and modulates p53 …

Webp53 dysfunction has previously been shown to activate PPP and contribute to the Warburg effect. ... Molina-Jimenez F, Benedicto I, Murata M, et al. Expression of pituitary tumor-transforming gene 1 (PTTG1)/securin in hepatitis B virus (HBV)-associated liver diseases: evidence for an HBV X protein-mediated inhibition of PTTG1 ubiquitination and ... WebSep 23, 2002 · a, Schematic diagram of human p53 and the shorter PTTG1-interacting TP53 cDNA. The structure of p53 is shown, including the transactivation domain (TA), DNA-binding domain (DB), tetramerization ... boat tours in niagara falls ontario

754 - Gene ResultPTTG1IP PTTG1 interacting protein

WebJun 21, 2024 · In addition, the existence of a complex network among p53 family members (p63 and p73) and their interactions with other factors that promote thyroid cancer progression has been well documented. ... The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells. Endocrinology 2014, 155, 1222–1234. [Google … WebFeb 1, 2011 · The expressions of Caspase-3, Bax, p21 and p53 in HepG2 and SMMC-7721 cells were significantly increased after siRNA knockdown of PTTG1 expression. In conclusion, the PTTG1 gene is up-regulated in the cancerous tissue from patients with HCC and involved in the progression of HCC. WebJul 16, 2010 · Significantly, the PTTG1-induced senescence is p53-dependent and telomerase-independent, which is distinctively different from that of replicative senescence. The mechanism of PTTG1-induced senescence was also analyzed. Consistent with its role in regulating sister-chromatid separation, overexpression of PTTG1 inhibited the … climate emergency strategy nhs scotland

Figure 4 Pituitary tumor-transforming gene 1 protein …

WebOct 1, 2015 · For example, PTTG1 (securin) specifically bound to p53 and interfered with DNA binding of p53, significantly reducing the transcriptional activity of p53 on p53-specific promoters . In this study, we present evidence that PTTG1, behaving as a miR-329, miR-300, miR-381 and miR-655 target gene, acts to mediate cell transformation and tumor formation. WebAug 23, 2024 · The p53 Signaling PCR array includes 24 genes involved in cell cycle regulation. Results indicate that nine of these genes were significantly altered in FLT samples. ... PTTG1 (Pituitary tumor-transforming gene 1) regulates the cell cycle by inducing cyclin D3 and repressing p21 expression . boat tours in nice franceWebNov 21, 2012 · Human pituitary tumor transforming gene-1 (PTTG1) is a novel oncogene. ... PTTG1 staining was one of the histological features (numerous mitoses, high Ki-67 index, and nuclear labelling of PTTG1 and P53) distinguishing aggressive–invasive PRL tumors from those behaving less aggressively ... boat tours in ocean city maryland

"WebSep 26, 2024 · pituitary tumor-transforming gene 1 protein-interacting protein, PTTG-binding factor, pituitary tumor-transforming gene protein-binding factor GeneRIFs: Gene References Into Functions protooncogene PBF is a negative regulator of p53 function in thyroid tumorigenesis, in which PBF is generally overexpressed and p53 mutations are … " - Pttg1 and p53

Pttg1 and p53

754 - Gene ResultPTTG1IP PTTG1 interacting protein

WebDec 25, 2024 · Nnegative pituitary tumor-transforming gene 1 protein-interacting protein (PTTG1IP) immunoexpression predicted a 1.5-fold risk of breast cancer death. ... protooncogene PBF is a negative regulator of p53 function in thyroid tumorigenesis, in which PBF is generally overexpressed and p53 mutations are rare compared with other tumor … Web[Pituitary tumor transforming gene 1 (PTTG1) is highly expressed and associated with poor prognosis in patients with hepatocellular carcinoma]. ... PTTG1 is overexpressed in nodular melanoma, and contributes to tumor progression by causing aneuploidy or by modulating p53-function; PTTG1 gene expression is mediated by Sp1 and is indirectly down ...

Did you know?

WebJul 8, 2004 · PTTG upregulates expression of p53 in HEK293 and MCF-7 cells. To determine the relationship between PTTG and p53, we first determined the effect of overexpression of PTTG on p53 expression. For this purpose, we used three different cell lines. Two of these HEK293, which is a human embryonic kidney cell line, and MCF-7, which is a human …

WebObjective To analyze the expression of pituitary tumor transforming gene 1 (PTTG1) in hepatocellular carcinoma (HCC) and its clinical prognostic implication. ... p53 signaling pathway and human T-lymphotropic virus (HTLV) infection. PTTG1 and its co-expressed genes were mutated to some extent in HCC, and significantly shortened OS and DFS in ... WebJul 28, 2008 · Pituitary tumor transforming gene 1 (PTTG1), a transforming gene highly expressed in several cancers, is a mammalian securin protein regulating both G1/S and G2/M phases. ... PTTG1 inhibits p53 ...

WebJul 28, 2024 · Pituitary tumor-transforming gene 1 (PTTG1) has been identified as an oncogene and is overexpressed in many tumor types. However, the role of PTTG1 in glioblastoma (GBM) has not been well characterized, especially in relation to angiogenesis, migration, and invasion. ... VEGF, MMP2, MMP9, MMP14, p53, p21 and cyclin D1. Pearson … WebOct 20, 2008 · They also observed apoptosis by PTTG1 in p53-negative MG-63 cells. The transient or stable expressions of PTTG1 in these cells were found to increase the frequency of aneuploidy. ... Puri R, Tousson A, Chen L, Kakar SS: Molecular cloning of pituitary tumor transforming gene 1 from ovarian tumors and its expression in tumors. Cancer Lett 2001 ...

WebJun 29, 2024 · Background Pituitary tumor transforming gene-1 (PTTG1) transcription factor is identified as carcinogenic and associated with tumor invasiveness, but its role in bladder cancer (BLCA) remains obscure. This research is intended to analyze the aberrant expression and clinical significance of PTTG1 in BLCA, explore the relationship between …

WebAug 17, 2011 · Cell lines and reagents. HCT116 is a human colon carcinoma cell line, expressing wild-type p53 and PTTG1 genes, and HCT116 p53 −/− and HCT116 PTTG1 −/− cell lines were derived using homologous recombination to knock out p53 or PTTG1 respectively , .Cells were cultured in McCoy's 5A medium containing 15% FBS. boat tours in niceWebThe PTTG1-Binding Factor (PBF/PTTG1IP) has an emerging repertoire of roles, especially in thyroid biology, and functions as a proto-oncogene. ... Impaired p53 function was evident in a transgenic mouse model with thyroid-specific PBF over-expression (PBF-Tg), which had significantly increased genetic instability as indicated by FISSR-PCR ... boat tours in old saybrook ctWebMar 21, 2024 · Pituitary tumor-transforming gene 1 protein (PTTG1_HUMAN) PTTG1 protein (Q2VPE7_HUMAN) cDNA, FLJ92498, Homo sapiens pituitary tumor-transforming 1 (PTTG1), mRNA (Q6IAL9_HUMAN) ... Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by … climate encounter limits computerWebFIGURE 3 p53 is required of PTTG1-induced senescence in normal cells. A, IMR-90 cells were infected with adenoviruses carrying GFP or PTTG1. Cell extracts were prepared 4 days after infection and then analyzed by … boat tours in orange beachWebFeb 25, 2024 · Pituitary tumor-transforming gene 1 (PTTG1) encodes a multifunctional protein that is involved in many cellular processes. However, the potential role of PTTG1 in tumor formation and its prognostic function in human pan-cancer is still unknown. ... Moreover, the UBE2C-mediated P53 ubiquitination could be a potential target in LIHC … climate emergency university of bathWebApr 9, 2024 · Background The present study aims to investigate the effects of pituitary tumor transforming gene (PTTG) 1 on breast cancer and its underlying mechanism. Methods GEO data set was applied to analyze the relationship between PTTG1 and survival status and the TCGA breast cancer dataset was used to explore its possible targets. The stable … climate emissions meaningWebJul 16, 2010 · To gain insight into the molecular basis of PTTG1-induced growth arrest and senescence in normal fibroblasts, we examined the expression pattern of several key cell cycle regulators that are involved in senescence using immunoblotting analysis.In IMR90 cells, PTTG1 overexpression consistently induced p53 expression and inhibited Rb protein … climate encounter computer policy