Ianthelline
WebbThe bromotyrosine derivative ianthelline was isolated recently from the Atlantic boreo-arctic deep-sea sponge Stryphnus fortis, and shown to have clear antitumor and antifouling effects. However, chemosystematics, field observations, and targeted metabolic … WebbLuna van der Loos, Sofie D’Hondt, Aschwin Engelen, Henrik Pavia, Gunilla B. Toth, Anne Willems, Florian Weinberger, Olivier De Clerck, Sophie Steinhagen Molecular Ecology - 2024
Ianthelline
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WebbWhile the precise mode of action of many anthelmintics is not fully understood, the sites of action and biochemical mechanisms of many of them are generally known. Parasitic helminths must maintain an appropriate feeding site, and nematodes and trematodes … WebbOrganic & Biomolecular Chemistry PAPER Cite this: Org. Biomol. Chem., 2016, 14, 11220 Received 29th September 2016, Accepted 9th November 2016 DOI: 10.1039/c6ob02120d
WebbIanthelline is shown to inhibit both marine micro- and macrofoulers with a pronounced effect on marine bacteria (minimum inhibitory concentration (MIC) values 0.1–10 μg/mL) and barnacle larval settlement (IC 50=3.0 μg/mL). Moderate effects are recorded on M. … WebbLänk till mer information om Gunnar Cervin. Förste forskningsingenjör med ansvar för den kromatografiska och mass-spektrometriska instrumentparken. Handledning, skötsel och metodutveckling på desamma. Tekniskt ansvar för projektgruppens fältbaserade och …
Webb24 feb. 2024 · Ianthelline (8) is an example of a bromotyrosine containing compound which was originally isolated from the Caribbean sponge Ianthella ardis (Litaudon and Guyot, 1986) and then later isolated from an Arctic sponge and tested for its AF bioactivity. Webb15 sep. 2010 · Ianthelline and JBIR-44 exhibit anticancer activity in HeLa cells and all the three compounds were cytotoxic towards HUVECs. In addition, this short synthetic route will allow for rapid development of analogues to explore structure–activity relationships.
WebbThis platform contains assays that can determine compound solubility, membrane permeability, phase I and phase II metabolic stability and metabolite identification. These results give us a good indication regarding the pharmacokinetic properties of our …
Webb23 juli 2014 · Ianthelline displayed low micromolar MIC values against several bacterial strains, both Gram positive and Gram negative, down to 2.5 μg/mL. In summary, the effect of ianthelline on 20 different representative marine antifouling organisms and seven … germaine hoffmanWebbIanthelline did not significantly inhibit ABL, but did provoke weak dose-dependent inhibition of PKA and PTP1B. It strongly inhibited the activity of 1 out of 131 tested kinases (to residual activity <10 %), with a Gini co-efficient of 0.22 for the degree of selectivity of … germaine hernandez obituaryWebbAntitumoral and Mechanistic Studies of Ianthelline Isolated from the Arctic Sponge Stryphnus fortis . × Close Log In. Log in with Facebook Log in with Google. or. Email. Password. Remember me on this computer. or reset password. Enter the email address … christine haney douglas ellimanWebb23 juli 2014 · Ianthelline displayed low micromolar MIC values against several bacterial strains, both Gram positive and Gram negative, down to 2.5 μg/mL. In summary, the effect of ianthelline on 20 different representative marine antifouling organisms and seven … christine hanlon ucfWebbIanthelline C15H17Br2N5O3 CID 46934566 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. christine hanlon njWebb30 nov. 2014 · The bromotyrosine derivative Ianthelline isolated from the Arctic marine sponge Stryphnus fortis inhibits marine micro- and macrobiofouling christine hanlon ucf rate my professorWebbThe Bromotyrosine Derivative Ianthelline Isolated from the Arctic Marine Sponge Stryphnus fortis Inhibits Marine Micro- and Macrobiofouling Author: Kine Ø. Hanssen, Gunnar Cervin, Rozenn Trepos, Julie Petitbois, Tor Haug, Espen Hansen, Jeanette H. … germaine hoston