Web验证码_哔哩哔哩 WebRather, Ars2 was required for survival of developing thymocytes and for limiting differentiation of bone marrow resident long-term hematopoietic stem cells. As a result, Ars2 knockout led to rapid thymic involution and loss of the ability of mice to regenerate peripheral blood after myeloablation. These in vivo data demonstrate that Ars2 ...
FlyBase Gene Report: Dmel\Ars2
WebFeb 12, 2024 · Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community. WebFeb 2, 2024 · A key regulator of RNA metabolism in the nucleus is the scaffold protein ARS2 (arsenic resistance protein 2), bound to the cap binding complex (CBC). We report here that alternative splicing of ARS2's intron 5, generates cytoplasmic isoforms that lack 270 amino acids from the N-terminal of the protein and are functionally distinct from nuclear ... thepowersource.us
Mapping domains of ARS2 critical for its RNA decay capacity
WebMar 29, 2024 · Ars2 is overexpressed in human cholangiocarcinoma and may be a diagnostic marker. Ars2 depletion increases PTEN and PDCD4 protein levels via the reduction of miR-21. Ars2 contributes to histone mRNA 3' end formation and expression and these functional properties of Ars2 are negatively regulated by interaction with 7SK RNA. WebFeb 12, 2015 · A version of an Ubuntu desktop is already up and running on the Raspberry Pi 2. The Pi 2 can run an Ubuntu 14.10 / Linaro 15.01 “developer” image with the LXDE … WebMay 28, 2024 · ARS2 facilitates the transcription termination and exosomal degradation of short RNAs, such as PROMPTs ().Hence, to interrogate a PROMPT-like and ARS2-dependent reporter, devoid of splicing signals, we employed a previously utilized exosome sensitive construct (), consisting of a short DNA sequence derived from the pcDNA5 … sif groutbor